Ipamorelin

Ipamorelin is a synthetic peptide that stimulates the Pituitary Gland to release Human Growth Hormone. It belongs to a class of compounds called growth hormone-releasing peptides (GHRPs), which work by mimicking the action of ghrelin, a natural hormone that regulates growth hormone release.

Ipamorelin is specifically designed to selectively increase GH without significantly affecting other hormones like cortisol or prolactin, which distinguishes it from some other GHRPs.

1. Growth Hormone Deficiency Research

Ipamorelin has been studied as a potential therapy for Growth Hormone Deficiency in adults and children.

Research indicates it can:

stimulate natural GH pulses from the pituitary

increase Insulin-like Growth Factor 1

support growth, metabolism, and tissue repair

Because it relies on the body’s own pituitary function, it is considered a “physiological” GH stimulator.

2. Body Composition and Muscle Research

Like other GH-stimulating peptides, Ipamorelin is studied for its effects on muscle and fat metabolism:

promotes lean muscle mass

supports fat metabolism

may aid in exercise recovery and muscle repair

Its selective mechanism helps minimize unwanted side effects linked to other GHRPs.

3. Aging and Somatopause

Growth hormone declines with age (Somatopause). Researchers are exploring Ipamorelin’s potential to:

counter age-related muscle loss

improve body composition

support metabolic health

enhance recovery and energy

Because it stimulates GH naturally, it is thought to mimic youthful GH rhythms more closely than direct GH injections.

4. Sleep and Hormone Rhythm

GH release occurs mainly during Slow-wave sleep. Ipamorelin has been studied for its ability to:

amplify natural GH pulses during sleep

support tissue repair

maintain circadian hormone patterns

Its short-acting nature makes it useful for research on physiological GH cycles.

5. Research on Pituitary Function and Endocrine Axis

Ipamorelin is also used in studies to evaluate the hypothalamic–pituitary–growth hormone axis, helping scientists understand:

pituitary responsiveness

GH pulsatility

interactions with other hormones (like ghrelin, cortisol, prolactin)

This helps develop safer GH therapies and study endocrine disorders.

✅ Important notes

Ipamorelin is primarily used in research and clinical studies.

It selectively stimulates GH without significantly increasing cortisol or prolactin.

It is often used in combination with CJC-1295 w/o DAC to enhance GH release while maintaining natural pulsatility.